Changes in temperature and ph can decrease an enzyme's activity by breaking

Changes in pH and temperature can decrease an enzyme's activity by breaking the shape or denaturing the shape of the biological catalyst, enzyme. It most likely will cause a change of the active site, preventing the specific substrates from binding to it undergoing a conformational change and producing the final products.

Mitochondria is the cell organelle that produced the energy that is needed in the body system in form of atp, that is why it is called the power house of the cell. energy is needed by the living organisms to carry out the activities which sustain life.  if the mitochondria is destroyed atp will not be produced. if the mitochondria is destroyed, energy production will stop and the affected living organism will not have the energy to carry out the necessary life processes; this will lead to the death of the organism.