How does the expression of Delta on the surface of a cell activate the expression of certain genes in the nucleus of its neighbor

Delta binds to the Notch receptor and this binding produces the cleavage of its intracellular domain, which subsequently enters into the cell nucleus to bind with a repressor in order to activate the transcription

Explanation:

The Notch signaling pathway is initiated when Notch receptors on the cell surface bind to the Delta ligand, which activates Notch signaling in cells next to it. In the receiving cell, Delta–Notch binding triggers the cleavage of the Notch intracellular domain called Nic (intracellular Notch). Subsequently, Nic enters into the cell nucleus where it releases repression on Suppressor of Hairless (Su(H)) class transcription factors, thereby activating the transcription of target genes.

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