When DNA strands are described as "antiparallel," what does that mean? a. The twisting nature of the DNA double helix creates nonparallel strands. ob One strand of the double helix is positively charged, and the other strand is negatively charged. Ос The 5' to 3' direction of one strand runs counter to the 5' to 3' direction of the other strand. d Base pairing creates unequal spacing between the two strands of the DNA double helix,