A researcher is setting up a randomized clinical trial to evaluate the effect of acetaminophen on liver function, and designates a control group of subjects and an experimental group of subjects. What could

interfere with the results or completion of this study?

Explanation:

Ordinarily, the control group will be the group that has reduced liver function but are provided with placebo while the experimental group will be the group that has reduced liver function and are treated with acetaminophen.

Some factors that could interfere with the results of this trial are

1) Some of the volunteers could have been on some medications before the trial started, that could affect the result of the study because the medications could hamper or improve the liver function or even the performance of the drug (if it is still present in the body system).

2) Some symptomatic volunteers could be using some medications (without the researcher's knowledge) to help alleviate the pain of the reduced liver function. These medications could also affect the result as discussed in the (1) above.

3) Some volunteers could have pre-existing health conditions (that may be known or unknown to them). This could also affect the result of the research as this pre-existing health condition could render the dosage of the drug "ineffective" or even contribute to the deterioration of the liver.

One major factor that could interfere with completion of the study is the availability of patients that will consent to be used as volunteers for clinical trial. Since there are other known/effective drugs for improving liver function, it might be difficult to convince people to consent to this trial thus elongating the completion time of this study

the statement is true

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