Biology, 20.11.2020 14:00 gshreya2005

Why do calculated recombination frequencies between pairs of loci that are located far apart underestimate the true genetic distances between loci? A. Recombination frequencies cannot exceed 50% and asymptotically approach 50% as the distance between genes increases because only one crossover can occur per chromosome. B. As the distance between loci increases, some multiple crossovers go undetected such that the relationship between recombination frequency and map distance ceases to be linear. C. Loci that are far apart on a chromosome often recombine to produce combinations of alleles that result in a lethal phenotype and such recombinants are not recovered or identified. D. Loci that are far apart on a chromosome are often susceptible to a form of chromatic interference that results in reduced crossing over, and this interference does not occur for loci that are closer together. E. If two crossovers occur between two loci, then only nonrecombinant gametes are produced; therefore, recombination frequencies actually begin to decrease for more distant pairs of genes.

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