The AQP1 gene in humans codes for the AQP1 protein (aquaporin-1), which allows water to pass through plasma membranes via osmosis. If there were a mutation to this gene that prevented the proper function of AQP1, which
option below best predicts the most likely outcome?
a. Cells would be unable to uptake water due to the non-functional AQP1 protein.
b. The mutation to the gene would cause a change in the amino acid sequence of the protein, which would
ultimately affect the protein’s 3D structure and function. This would allow for more water to be taken up by
cells.
c. Cells would still be able to uptake water, as water can pass through the cell membrane without the assistance
of aquaporins. However, it would take up water at a much slower rate because water has a slight charge.
d. A change in shape and function of the protein would prevent ATP from transferring its terminal phosphate
group to the aquaporin, thus preventing water from passing through the channel.