Imagine you are a genetic counselor and a couple has asked you to determine the probability of their child developing a genetic disease, given their family history below. Husband’s family history:
The husband has the disease.
The family history of the husband is unknown.

Wife’s family history:
The wife does not have the disease.
The wife has a sister without the disease and a brother with the disease.
Both of the wife’s parents have the disease.
The wife’s father is an only child; his father has the disease, but his mother does not.
The wife’s mother has two brothers without the disease; her mother had the disease, but her father did not.

is this disease autosomal or sex-linked?
Explain how you know the disease allele is autosomal or sex-linked. Use specific relationships (between family members) to support your claim.