why are Gram-positive bacteria are more resistant than Gram-negative bacteria to antimicrobials that disrupt plasma membranes

Gram positive bacteria are more resistant than gram negative bacteria to antimicrobials that disrupt plasma membranes because they have cell wall that is made up of a thick layer of peptidologlycan that contain teichoic and lipoteichoic acid to peptidoglycan.

Explanation:

Gram positive bacteria are bacteria that have thick wall made up of peptidoglycan and have no lipid membrane while gram negative bacteria are bacteria that have thin cell wall composed of peptidoglycan with lipid membrane.

Gram positive bacteria is resistant to antibiotics because of their thick cell wall composed of peptidoglylcan which contain teichoic and lipoteichoic acid , this help strengthen the plasma membranes and make them not to be attached by antimicrobial compared to gram negative that lack this.

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