Discuss the effects of histone modification and DNA modification on transcription. Describe ways in which marks can activate and repress transcription for both types of modification. For all modifications, describe any known mechanisms of action

List the advantages and disadavantages of the switch from persistent chlorinated hydrocarbon pesticides (such as ddt) to nonpersistent organophosphate pesicides. have the benefits of the switch outweighed the disadvantages? explain.

Mr. j, age 42, is a construction worker in las vegas. he recently noticed that a mole on his face seemed to be getting larger and darker. at first he did not worry because he was in the sun a lot and assumed the change may have been caused by sunburn. after a month, not only was the mole larger and darker, but it appeared to be “bumpy.” his doctor diagnosed a malignant melanoma skin cancer following biopsy of the nevus. mr. j reports pain in his right shin that does not go away when he puts his feet up or sleeps. discussion questions 1. relate mr. j’s skin changes to the warning signs for malignant melanoma. (see malignant melanoma.) 2. discuss the normal progression of this malignancy. what is the significance of the bone pain that mr. j is experiencing? (see malignant melanoma.) 3. discuss the treatment available for this patient and the prognosis for recovery. (see malignant melanoma.)

Using the gas pedal analogy explain the impact on the cell cycle of one mutated tumor suppressor gene allele versus two mutated tumor suppressor alleles