What are three different defects that could be responsible for malfunctioning lysosomes?
select the three correct answers.
a) a defect in the synthesis of the glucose-6-phosphate dehydrogenase
b) a defect in the mannose-6-phosphate receptor in the golgi apparatus
c) a defect in the releasing small molecules from digested materials into the cytosol
d) a defect in a hydrolytic enzyme that breaks down polysaccharide
e) a defect in the process of adding a mannose-6-phosphate signal to lysosomal hydrolases
f) a defect in the mannose-6-phosphate receptor in the mitochondria

B); D) and E)

Explanation:

B) a defect in the mannose-6-phosphate receptor in the Golgi apparatus.

Explanation: The mannose-6-phosphate receptors (MPR's) in the Golgi apparatus are essential for targeting the mannose-6-phosphate tagged lysosomal proteins to the lysosome.

D) a defect in a hydrolytic enzyme that breaks down polysaccharide.

Explanation: Lysosomes contain enzymes that hydrolyze polysaccharides, therefore any defects in these enzymes causes malfunctioning of the lysosome.

E) a defect in the process of adding a mannose-6-phosphate signal to lysosomal hydrolases.

Explanation: In the Golgi apparatus lysosomal proteins are tagged with mannose-6-phosphate so that they are specifically transported to the lysosomes.  

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