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Biology, 07.10.2020 22:01 itz0nlyheav
Mutations in several different genes that encode enzymes in the pathway for the synthesis of the heme group may cause a genetic disorder called methemoglobinemia. The symptoms of this disorder range form mild to death in the most severe cases. The enzyme cytochrome b5 reductase is one of the enzymes in this pathway. This enzyme is responsible for reducing the iron in the heme group to the ferrous state so that it can bind oxygen. Kobayashi et al. reviewed several mutations in this gene. One of these mutations causes a Ser to Pro substitution. Explain what nucleotide change and in which position in the codon can cause this amino acid change. Assign all possible appropriate terms to this mutation.
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