In the glycolytic pathway, glucose 6-phosphate. a six-carbon sugar, IS isomerized to fructose 6-phosphate. Two steps after the isomerization reaction, the six-carbon Sugar is cleaved to form two three-carbon sugars. Choose the statements that describe why the isomerization reaction is critical for the subsequent cleavage reaction that results in formation Of two three-carbon sugars in the glycolytic pathway?a. The carbon of a carbonyl group has a partial positive charge and can delocalize electrons to facilitate cleavage of the C-C bond. Without the isomerization reaction, C-1 will be the carbonyl carbon and the C— C cleavage will occur between C-2 and C-3. b. Breaking a bond is energetically unfavorable and can only proceed if a functional group with electronegative atoms is adjacent to the cleavage site to stabilize the reaction intermediates. c. To cleave a bond, a nucleophilic carbon attacks the adjacent electrophilic carbon. The isomerization reaction moves the carbonyl group to C-2, thus making it a nucleophile that can attack C-3 to generate two three-carbon sugars. d. The partial positive charge on the carbonyl carbon can stabilize the carbon radicals formed by the homolytic cleavage Of the C— C bond in the six-carbon sugar. Since the cleavage occurs between C-3 and C-4 Of the six-carbon sugar, the carbonyl group needs to be on C-2. e. Cleavage of a C—C bond in the six-carbon sugar occurs via a decarboxylation reaction that requires a carbonyl group adjacent to cleavage site to stabilize the carbanion intermediate.