Prompt Comparing amino acid sequences in proteins has been used to determine the relatedness of organisms. Below is a graphic that shows the amino acid sequence differences between different organisms for a protein keratin. Changes in amino acid sequences are known to cause changes in structure of proteins. Part A. Consider species A, D, and E. Using the data provided, describe how the structures of their keratin proteins would compare. Part B. Keratin is made up of about 450 amino acids. Determine the similarity in percentages between species A and B, A and C, and B and C. Explain how amino acid sequences can be used in determining how closely related two species are. Part C. Based on this data, predict which two species would be more closely related to one another. Part D. Justify your predictions to part C.

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This is the answer to A) Describe how allosteric enzymes are regulated by activator and inhibitor regulatory molecules.

B) Explain how ATP and ADP act as allosteric regulators of enzymes that are responsible for ATP production, and how that is an example of feedback inhibition.

C) What is feedback inhibition? How is the ATP generating pathway discussed in part B an example of feedback inhibition?

a} Allosteric regulation is just any form of regulation where the regulatory molecule (an activator or inhibitor) binds to an enzyme someplace other than the active site.The shape of the active site is changed, allowing substrate to bind at a higher affinity.

b) The molecules that bind cellular respiration enzymes act as signals, giving the enzyme information about the cell's energy state. ATP, ADP, and NADH are examples of molecules that regulate cellular respiration enzymes. ATP, for instance, is a "stop" signal: high levels mean that the cell has enough ATP and does not need to make more through cellular respiration.

c) This is a case of feedback inhibition i in which a product feeds back to shut down its pathways.

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