Prior to implementing any significant change in the use of animals, what is the most important thing that the research team must do

obtain IACUC approval for the change.

Explanation:

The most important thing that the research team must do is to obtain IACUC approval for the change. This is because the institutional animal care and use committee (IACUC) is a requirement for any institution using animals as test subjects for their research, teachings, and/or testing. This committee focuses on making sure that the animals are not being tortured or harmed and that the testing is done correctly.

i got you i did it ya know what it is just needing to fill this in for a quick task!