Which best contrasts self-renewal and differentiation?

Self-renewal is a kind of cell division specific to stem cells, so cell division is a general term. When self-renewal occurs, a stem cell divides into two cells, one of which is still a stem cell (which can display differentiation potential into one or more types of differentiated cells (stemness/potency) and divides almost indefinitely = self-renewal), and another is a differentiated cell, which may or may not divide, but its divisions (if any) are not self-renewal because (1) no stem cell (i.e. a cell with developmental potential) is produced, and (2) these divisions are finite (so they are not self-renewal, because self-renewal is indefinite yet controlled proliferation). In sum, self-renewal is a stem cell's 'unlimited' division while retaining its developmental potential.

Of note, stem cell immortality is thanks to the expression of the enzyme telomerase.

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