As part of a cancer research project, you have discovered a gene that is mutated in many metastatic tumors. After determining the DNA sequence of this gene, you compare the sequence with those of other genes in the human genome sequence database. Your gene appears to code for an amino acid sequence that resembles sequences found in some serine proteases. Conjecture how your new gene might contribute to the development of highly invasive cancers. Drag the terms on the left to the appropriate blanks on the right to complete the sentences.

encouraged

protecting

lower

reduced

higher

promoting

1. Proteases in general and serine proteases specifically are considered tumor-promoting agents because they degrade proteins, especially those in the extracellular matrix. When such proteolysis occurs, cellular invasion and metastasis are__encouraged . Consistent with this observation are numerous observations that metastatic tumor cells are associated with higher than normal amounts of protease expression. Inhibitors of serine proteases are often tested for their anticancer efficacy.

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