How are changes in hox genes significant in the evolution of species?

Hox genes help lay out the basic body forms of many animals, including humans, flies, and worms. They set up the head-to-tail organization. Small changes in such powerful regulatory genes, or changes in the genes turned on by them, could represent a major source of evolutionary change.

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Explanation:

yes we can.   a lady urinates from her urethra.