The net equation for the oxidative reactions of the pentose phosphate pathway is

glucose−6−phosphate+2NADP^+ +H2O⟶ ribulose−5−phosphate+2NADPH+CO2+2H+

Select true statements about the pentose phosphate pathway.

a. The pentose phosphate pathway contributes to nucleotide synthesis.
b. Glucose‑6‑phosphate is common to glycolysis and the pentose phosphate pathway.
c. Carbon atoms from the pentose sugar products may enter the glycolytic pathway.
d. NADP+ is oxidized to NADPH in the pathway.

Correct options are

A: "The pentose phosphate pathway contributes to nucleotide synthesis."

B: " Glucose‑6‑phosphate is common to glycolysis and the pentose phosphate pathway."

Explanation:

Both these statements are true. The end product of pentose phosphate pathway is the ribose-5-phosphate sugar, which forms the backbone in the structure of DNA and RNA. A glucose‑6‑phosphate molecule is formed during the very first step in glycolysis (due to addition of a phosphate group to glucose). It is this very glucose‑6‑phosphate molecule that is oxidized during the pentose phosphate pathway to lactone.

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