Why were mutations needed for the species of moth to survive during the Industrial Revolution in London?

Humans are believed to have evolved in coastal regions in east africa. the region had an abundant supply of fish for early humanoids to eat. when scientists analyze the fads gene they see an interesting pattern. people whose families have lived in this area of east africa for generation show a high level of diversity in alleles for the fads gene. conversely, people whose families had migrated inland a moderate distance from sources of fish showed a much lower diversity for fads gene alleles. additionally, the fads alleles found in people whose family has lived inland for generation are almost all gene alleles which produce fads proteins with a high level of function and activity. how do anthropologists explain this?

Restless tectonic plates move (shift) between one and fifteen centimeters per year month day minute

Omg substrates with the same size and shape as the active site will bind to the enzyme. why is the key labeled the “bad” substrate?