A dry mouth stimulates the thirst center, located in the . in the volume and/or in the osmolality of plasma, as well as and rising levels of blood stimulate the of the thirst center. After water intake, moistening of the mouth and throat mucosae and activation of receptors in the send signals that inhibit the thirst center (negative feedback). This mechanism rapidly satisfies thirst and prevents excessive of body fluids. After thirst is quenched, a(n) in plasma osmolality causes the kidneys to begin eliminating excess water. Inhibition of the release of hormone leads to excretion of large volumes of urine. Regulation of water balance by kidney activity is closely related to ion concentration. Uncontrollable water losses in urine are called water losses. To maintain blood homeostasis, the kidneys must excrete a minimum of ml of water per day to get rid of about 600 mmol of water-soluble ions.