The "Danbury shakes" was a colloquial name for a series of neurological symptoms, including tremors, commonly exhibited by workers in the hat manufacturing industry in Danbury, Connecticut. The symptoms were caused by the use of mercury nitrate to produce felt, a practice that was not banned in the United States until 1941. The administration of thiol‑containing reagents, such as dimercaprol, has long been used as a treatment to counteract mercury poisoning.
What is the biochemical explanation for the symptoms of neurological dysfunction displayed by workers exposed to mercury nitrate?
a. The E1 component of pyruvate dehydrogenase complex is unable to form hydroxyethyl‑TPP, blocking the citric acid cycle in cells of the brain.
b. The dihydrolipoamide group of pyruvate dehydrogenase complex is inactivated, preventing the complete oxidation of glucose in the brain.
c. The inhibition of pyruvate dehydrogenase complex means NADH/NAD+ and ATP/ADP ratios are constantly elevated in the brain.
d. Gluconeogenesis is blocked due to pyruvate dehydrogenase complex inhibition, which starves neurological tissue of glucose.
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