T-cell activation requires antigen being displayed in the context of an APC and interaction between co-stimulatory molecules on the APC and the T cell. In addition to these two signals, T cell activity is often influenced by cytokines. Which of the following is an example of how cytokines can influence T-cell activity in the presence of MHC presentation and costimulatory ligand interaction

A. Antigen-specific TCR binding to MHC peptide
B. Expression of CD4+ or CD8+
C. Interaction with CD80, CD86, or ICOS-L
D. Both A and B
E. Both A and C