How will ATP synthesis from glucose metabolism change in muscle cells deficient in triose phosphate isomerase?

a. ATP synthesis will not change.
b. No ATP will be synthesized.
c. One less ATP molecule will be synthesized.
d. The amount of ATP synthesized will decrease by one half.

The correct answer is d. "The amount of ATP synthesized will decrease by one half".

Explanation:

Triose phosphate isomerase (TPI) is an enzyme that catalyzes the reversible conversion between two molecular intermediates in the glycolysis process. TPI is essential for glycolysis and it has been found in all organisms that perform it. TPI is needed for an efficient energy conversion. Triosephosphate Isomerase Deficiency is a rare autosomal disorders at which the rate of ATP synthesis is reduced considerably, while the amount of dihydroxyacetone phosphate (DHAP) is elevated.

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