Quizl;et Anemia associated with deficiency of either vitamin B12 ( Cobalamin ) or folic acid ( B9 ) is characterized by enlarged ( macrocytic ) red blood cells. Together these are known as the megaloblastic or macrocytic anemias. Megalo and macro mean large, and in these anemias the red blood cells and their bone marrow precursors ( blast cells ) are unusually large. Clinically, the two deficiencies are very similar, except for the

Clinically, the two deficiencies are very similar, except for the CHARACTERISTIC DEFECT they cause

Explanation:

Megaloblastic or Macrocyctic anaemia are anaemias or a very low blood level that is caused by a deficiency in folic acid or Vitamin B12 in the body. The deficiency in these nutrients cause the red blood cells of the body to become enlarged.

Although Megaloblastic and Macrocyctic anaemia are similar by definition as well as clinically, they have a very slight difference in the defect they cause to the red blood cells.

Megaloblastic anemia cause a CHARACTERISTIC NUCLEAR DEFECT while Macrocyctic anemia causes a CYTOPLASMIC MATURATION DEFECT.

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