Which of the following statements comparing the targeting of a mitochondrial matrix protein to the targeting of a protein to the ER is/are correct? Choose all that apply.

-Proteins translocated into either compartment have an equal chance of ultimately being localized to the outside of the cell.
-Insertion of proteins into both compartments takes advantage of an energy source in the form of an electrochemical gradient.

-Proteins destined for either compartment require sequences of amino acids which serve as targeting signals.
-Proteins destined for either compartment are inserted into their respective compartments in an unfolded state.
-The same signal can be used to direct a protein to either compartment, as long as the appropriate receptor recognizes the signal.
-Proteins destined for either compartment are allowed to fold in the cytoplasm and then are unfolded prior to insertion into their respective compartments.
-Proteins destined for either compartment are likely to retain their amino terminal targeting signals.