If administration of a drug is suspected to reduce the alkaline phosphatase level, how would you test for it using a level of signi cance = 0:10: Use the (i) critical value method (ii) p-value method and (iii) con dence interval. Draw proper conclusions in each case.

Yed

Explanation:

A rise in the alkaline phosphatase occurs with all forms of cholestasis, particularly with obstructive jaundice. It is also elevated in diseases of the skeletal system, such as Paget disease, hyperparathyroidism, rickets and osteomalacia, as well as with fractures and malignant tumors. A considerable rise in the alkaline phosphatase activity is sometimes seen in children and juveniles. It is caused by increased osteoblast activity following accelerated bone growth.

layer 3 is younger than layer 6.