E following are important steps in the process of endochondral ossification. What is the correct order for these events? 1. Enlarged chondrocytes die. 2. Osteoblasts replace calcified cartilage with spongy bone. 3. Chondrocytes enlarge and the surrounding matrix begins to calcify. 4. Blood vessels grow around the edges of the cartilage. 5. Perichondrial cells become osteoblasts and produce a superficial layer of bone.

The correct order for these events is 3, 1, 5, 4, 2

Explanation:

Endochondral ossification is referred to as the process of bone development from hyaline cartilage. Cartilage is systematically replaced by bone to form the growing skeleton. Endochondral ossification process involves chondrocytes enlarge and the surrounding matrix begins to calcify, enlarged chondrocytes die, perichondrial cells become osteoblasts and produce a superficial layer of bone, blood vessels grow around the edges of the cartilage, and osteoblasts replace calcified cartilage with spongy bone.

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