In organisms with large genomes, inversions are more likely to be tolerated if the breakpoints occur in: reciprocal translocations. noncoding DNA. open reading frames. coding DNA. closed reading frames.

Non-coding DNA.

Explanation:

Inversion is a type of chromosomal abnormality in which the sequence of a segment of a chromosome is inverted or rotated at an angle of 180 degrees.  This type of abnormality can change the reading frame of the gene and can cause mutations.

But if the genome sequence is non-coding that is not involved in the formation of protein synthesis than even if the reading frame is inverted will not affect the phenotype of the cell. Also, the non-coding sequences are removed by the splicing mechanisms.

Thus, Non-coding DNA is correct.