Gram-1 cells are more susceptible to penicillin than Gram-2 cells because the thick 3 cell walls of Gram-positive cells are critical for their function. Gram-negative cells also contain an outer4, which excludes small molecules, such as antibiotics

1: positive, 2: negative, 3: layer of peptidoglycan, 4: thin layer of peptidoglycan and slime body

Explanation: gram-positive cells are more receptive and susceptible to penicillin and/or cell wall targeted antibiotics despite their thick layer of peptidoglycan. However, gram-negative cells which has a thin layer of the peptidoglycan but it possesses slime body which helps them to wade off antibiotics attacks. This helps them to become resistance to antibiotics and makes them stronger.

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check for the pregnancy rating of drug. if its class c or d see if other alternatives