Tetrahydrocannabinol, the active ingredient in marijuana, binds to receptors located in the terminals of certain brain neurons. It lowers the likelihood that these neurons will release .

This question lacks options, the options are:

a. Presynaptic; Ca2+ ions

b. Postsynaptic; Ca2+ ions.

c. postsynaptic; neurotransmitters

d. presynaptic; neurotransmitters

e. dendritic; neurotransmitters

The correct answer is d. Tetrahydrocannabinol, the active ingredient in marijuana, binds to receptors located in the presynaptic terminals of certain brain neurons. It lowers the likelihood that these neurons will release neurotransmitters .

Explanation:

Tetrahydrocannabinol is the most abundant cannabinoid in most cannabis varieties and has the most potent psychoactive effect. Conventional neurotransmitters are water-soluble substances stored in small vesicles at the thin ends of the axon (presynaptic terminals). When a neuron generates an impulse by sending an electrical signal along the axon to the presynaptic terminals, the neurotransmitters are released from the vesicles, diffuse through a narrow intercellular space (synaptic cleft) and interact with the receptors on the surface of the recipient neuron (postsynaptic neuron). Cannabinoids cause a decrease in the release of neurotransmitters from the presynaptic terminal through the inhibition of Ca++ channels. This signaling is mediated by the βγ subunit of the G protein. The βγ subunit of the G protein inhibits the Ca channels of type N and P / Q, which are the majority in presynaptic neurons.

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