Complete the sentences to explain why is it important that ES is not too much more stable than E +S. Determine how this is related to the lock and key versus induced fit models of enzyme function. Match the words in the left column to the appropriate blanks in the sentences on the right. Reset Help increases Enzymes catalyze reaction by stabilizing the transition state. If the enzyme binds to the substrate too well, the activation energy for the catalyzed reaction decreases. Thus, the enzyme binds best to the substrateand the activation energy remains about the same lock and key transition state decreases remains about the same substrate In the lock and key model, the enzyme binds to the substrate most efficiently. In the induced fit model, both the enzyme and substrate change their structure upon binding in a way that favors the formation of the enzyme-substrate complex enzyme-substrate complex Thus, when comparing the models, the induced fit model lowers the energy of the transition state induced fit more