What is the effect of defective or missing N-acetylglucosamine phosphotransferase on lysosomal protein sorting?

The deficiency in this enzyme causes that it begins erroneously label other enzymes. Because the activating proteins are not properly labeled, they escape into spaces outside the cell and do not disintegrate substances inside the cells, that is, lysosomes cannot perform their function correctly. This causes waste products, which must include carbohydrates, lipids and proteins, accumulate in specific masses as inclusion bodies.

homeostasis is the tendency towards a relatively stable equilibrium between interdependent elements, especially as maintained by physiological processes. and this is how it applies to the integumentary system. back to top. skin functions in homeostasis include protection, regulation of body temperature, sensory reception, water balance, synthesis of vitamins and hormones, and absorption of materials. when body temperature falls, the sweat glands constrict and sweat production decreases.