Which of the following is a difference between primary and secondary active transport? Which of the following is a difference between primary and secondary active transport? In primary active transport, the transport protein gets phosphorylated; in secondary active transport, the transport protein is not phosphorylated. Primary active transport is driven by secondary active transport. Energy is required for primary active transport, but not secondary active transport. Primary active transport moves solutes in opposite directions while secondary transport moves solutes in the same direction