If you were to suffer a random injury to your brain, why would it be a safe bet that the structure most likely to be damaged would be the cerebral cortex?

The cerebral cortex, being that it is Tue most active part of the cerebrum and with wide surface area

Explanation:

The cerebral cortex is an ACTIVE OUTER LAYER that covers the entire surface area of the cerebrum, which happens to be the largest part of the brain. Also, the ability of the cerebrum increase as the cerebral cortex becomes more developed.

So due to the protective role and wide surface area of the cerebral cortex, it is definitely the most likely part to suffer random injury.

substitution is the answer in this case