Cb1 agonists such as tetrahydrocannabinol (thc) reduce calcium influx by blocking the activity of voltage-dependent calcium channels. what effect would this have on the release of glutamate? agonists such as tetrahydrocannabinol () reduce calcium influx by blocking the activity of voltage-dependent calcium channels. what effect would this have on the release of glutamate? exocytosis of vesicles containing glutamate from the nerve terminal would increase. exocytosis of vesicles containing glutamate from the nerve terminal would decrease. there will be no effect.