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Which statements are true regarding the citrate cycle? a. mutating histidine residue 274 of the citrate synthase enzyme to an alanine amino acid would likely eliminate or reduce the enzymatic activity of citrate synthase. b. the histidine residue would hydrogen bond to acetyl-coa throughout the reaction mechanism, stabilizing the enolate intermediate. c. aspartate would behave as an acid in this reaction mechanism. d. oxaloacetate would be repulsed from aspartic acid in the first step of the reaction mechanism.
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