Summarize how crigler-najjar syndrome affects the human body as a disorder progress

The type 1 Kernicterus, of the Crigler-Najjar syndrome can cause death and the second type is less serious than first type and causes jaundice in new borns.

Explanation:

The syndrome of Crigler- Najjar is caused by the mutation of the gene UGT1A1. This gene carries information about the production of uridine-disphospate, liver enzyme that helps in excreting bilirubin from human body.  The absence of this gene causes failed excretion of bilirubin leading to high increase of it in the body.

The excessive bilirubin crosses the blood barrier of the brain and affects it causing this syndrome.  The 1st type, Kernicterus is severe and can cause death but the second one is less acute and cause jaundice in newborns.