Which molecule is a first messenger but not a second messenger

Hormones act as first messenger but not as second messengers.

Explanation:

Second messenger act as signaling molecule which are secreted in response to various biological signals generated by first messenger such as hormones,neurotransmitters etc.Second messengers include various bioactive molecules such as cyclic AMP(cAMP),cyclic GMP(cGMP),inositol triphosphate(IP3),diacylglycerol(DAG),calcium ions(Ca2+) etc.

         Hormones are extracellular signaling molecules whereas second messengers are intracellular signaling molecules.

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