What is the primary difference between prokaryotic and eukaryotic cells?
prokaryotic cells use ribosomes to manufacture proteins, whereas eukaryotic cells do not.
eukaryotic cells have membrane‑bound compartments called organelles, whereas prokaryotic cells do not.
eukaryotic cells have chromosomes that contain instructions for the cell, whereas prokaryotic cells do not.
eukaryotic cells have a cell membrane surrounding the cell, whereas prokaryotic cells have a cell wall.
prokaryotic cells contain mitochondria, whereas eukaryotic cells contain chloroplasts.

Here, we are required to establish the primary difference between prokaryotic and eukaryotic cells.

The primary difference is that; Eukaryotic cells have membrane‑bound compartments called organelles, whereas prokaryotic cells do not.

Although other differences are present in Prokaryotic and Eukaryotic cells, the primary difference between them lies in the fact that Eukaryotic cells have several other membrane-bound organelles which are absent in prokaryotic cells.

These organelles include the mitochondria (which is responsible for the conversion of food energy into adenosine triphosphate, or ATP, to power biochemical reactions); rough and smooth endoplasmic reticulum (which is a network of membrane-enclosed tubules that transport proteins upon their synthesis); golgi complex (responsible for sorting and packaging proteins for secretion); and in plant cells, chloroplasts (responsible for photosynthesis).

All of the organelles mentioned above are bound by the membrane of eukaryotic cell's otherwise known as cytoplasm.

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cells spend most of their time in interphase