Changes in the genetic make-up are normally
to the organism.
harmful
irrelevant

Harmful

Explanation:

The change in the genetic makeup simply describes the change in the sequence of genes. This can be a result of mutation. The mutation are beneficial sometimes but not always.

The change in the sequence will change the protein product by the gene. This will create problem in normal functioning by the product when the normal expression was there. Thus, changes in genes are harmful to organism.

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hydrogen is a compound or a single element and a element is a pure substence that cannot be separated into simpler subtances

clorine is a compound its a chemical substance that forms when two or more different elements combine

so both hydrogen and clorine are compounds