Galactosemia can result from a deficiency of either galactokinase or udp-glucose: galactose 1-phosphate uridylytransferase (transferase). although a deficiency of either enzyme will cause gastric discomfort after milk ingestion, transferase deficiency also results in liver, kidney, spleen, and brain dysfunction, and in some cases, death. for each type of enzyme deficiency, identify which metabolites accumulate in the blood and tissues. a transferase deficiency will cause an accumulation of udp-glucose a galactokinase deficiency will cause an accumulation of galactose. □ transferase converts galactose 1-phosphate to udp-galactose; therefore, a transferase deficiencywill cause an accumulation of galactose 1-phosphate. a deficiency in either enzyme will result in an accumulation of lactose; however, a transferase deficiency will also cause an accumulation of the toxic product udp-galactose. a galactokinase deficiency will result in an accumulation of galactose 1-phosphate