Which of the following is most directly responsible for the coupling of excitation to contraction of skeletal muscle fibers? acetylcholine. action potentials. calcium ions. sodium ions.

Calcium ions

Explanation:

The excitation-contraction coupling process is the process by which the electrical activation of muscles (the depolarization of the action potential) leads to the activation of contraction.

An action potential in the skeletal muscles or muscle excitation leads to Ca release from the sarcoplasmic reticulum via calcium channel protein. Released Ca regulates the contraction of the muscle.

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