Which statement most accurately explains how allosteric regulation can change an enzyme's catalytic activity? view available hint(s) which statement most accurately explains how allosteric regulation can change an enzyme's catalytic activity? in allosteric activation, a regulatory molecule binds to a location other than the active site, resulting in a change in enzyme shape that allows the active site to bind substrate. in allosteric activation, a regulatory molecule binds to the active site, allowing substrate binding. in allosteric inhibition, a regulatory molecule binds to the active site, blocking substrate binding. in allosteric inhibition, a regulatory molecule binds to a location other than the active site, resulting in a change in enzyme shape that allows the active site to bind substrate.