Which of the following substances would have the most trouble crossing a biological membrane by diffusing through the lipid bilayer?
a. co2
b. h2o
c. a small, nonpolar molecule such as butane (c4h10)
d. na+
e. o2

Answer;

d. Na+

Explanation;The cell membrane's main trait is its selective permeability, which means that it allows some substances to cross it easily, but not others. Small molecules that are non-polar (have no charge) can cross the membrane easily through diffusion, but ions (charged molecules) and larger molecules typically cannot.Charged ions  such as N+ and K+ Cannot permeate the cell membrane for the since uncharged molecules repel uncharged molecules present in the membrane structure.

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Used to water and cool climates, probably not thick coated or fluffy. they most likely have thin coats and have to survive to find food. sorry if this wasn't the answer you were looking for..: )