How does a noncompetitive inhibitor decrease the rate of an enzyme-catalyzed reaction? a) by binding to the active site of the enzyme, thus preventing binding of the normal substrateb) by binding to an allosteric site, thus changing the shape of the active site of the enzymec) by decreasing the free-energy change of the reaction catalyzed by theenzymed) by binding to the substrate, thus changing its shape so that it no longerbinds to the active site of the enzyme