Is the structure of dna important for the process of dna replication?

Basically structure of DNA is very important in the process of replication.

DNA molecules have antiparallel structure i.e. the two strands of the halix run in opposite directions of one another. Each strand has 5 prime end and 3 prime end. Solving the structure of DNA unlocked the door to understanding many of the function of DNA, such as how it copied and how the information it carries can be used to produce protein.

the principles and empirical processes of discovery and demonstration considered characteristic of or necessary for scientific investigation, generally involving the observation of phenomena, the formulation of a hypothesis concerning the phenomena, experimentation to test the hypothesis, and development of a conclusion that confirms, rejects, or modifies the hypothesis.