1. if the dna sequence tca had a one base substitution to make it taa, which statement best describes how it would affect the protein? a. even though one letter changed, the same amino acid would still come in, so the protein wouldn't be altered. b.even though one letter changed, and one amino acid changed, the color of the amino acid stayed the same. therefore the protein's shape would not be altered. c.one letter changed and now instead of it being a white hydrophilic amino acid it is a yellow hydrophobic amino acid. this would cause the folding of the protein to alter as the yellow amino acid would force its way to the center of the protein. d.one letter changed and that would alter the entire reading frame of the protein and it would be so messed up a protein wouldn't even form.2.if the shape of the acid alpha-glucosidase (gaa) enzyme changes, how would that affect the enzyme’s job in the cell? a. enzymes are like a lock and key, so if you changed the shape of the lock (gaa enzyme), the key (the glycogen) would no longer fit and wouldn't be able to get broken down into glucose. b. enzymes are like a lock and key, so if the enzymes shape changes, it will then get used up by the gaa and won't be available to break down glycogen. c.there are so many gaa enzymes that it won't matter if the shape of one changes. the other enzymes will be able to work properly and break down the glucose. d. the enzyme's job is to break down the glycogen in the lysosomes of the cell.3. if there is a mutation in the dna that prevents the gaa enzyme from doing its job, what will happen to the structure and function of the lysosome? a. the lysosome will swell and expand in size (structure) and it will not be able to break down the glycogen that is going to build up in the lysosome (function).b. the lysosome will remain a small sac (structure) and the acid inside it will break down the glycogen (function).c. the lysosome will shrink (structure) because it is sitting in a hypertonic solution, so the acid will diffuse out of the lysosome (function).d. the lysosome will burst and acid will get all over the cell.4. how does the change in the lysosome structure and function result in the symptoms of pompe disease? a. the muscles will get weak because there will be less and less lysosomes. b. they lysosomes will shrink because they are losing acid which will not allow nutrients to move from the blood to the cells causing the patients to become weak. c. the acid leaking out of the lysosomes will break down the skin cells that it comes into contact with. d. when the glycogen builds up, the lysosomes will expand taking up so much space that it can damage the surrounding muscle cells causing muscle weakness in the body.