Connective tissues are made of different combinations of ground substance and fibers. as you compare slides of connective tissues, which would most likely be the strongest (toughest) type of connective tissue based on the composition of ground substance and fibers? connective tissues are made of different combinations of ground substance and fibers. as you compare slides of connective tissues, which would most likely be the strongest (toughest) type of connective tissue based on the composition of ground substance and fibers? connective tissue high in elastic fibers connective tissue high in ground substance connective tissues high in collagen fibers connective tissue high in reticular fibers