Tay-sachs disease is caused by a mutation in the hexa gene located on chromosome 15. tay-sachs follows an autosomal recessive pattern of inheritance. with the of the diagram, identify which of the offspring will be an unaffected carrier. a. a, b, and c b. b and c c. a and d d. a e. d

The unaffected carrier individual, is the one who has only mutated gene of the autosomal recessive disease.

The right answer is B and C individuals

The genes responsible for autosomal recessive (AR) transmitted diseases are localized on autosomes.

The mutated allele responsible for the disease is recessive on the wild allele; heterozygotes are healthy and the disease is expressed only in homozygotes.

Tay-Sachs disease is a neurodegenerative disease caused by a deficiency of hexosaminidase causing an accumulation of ganglioside GM2.

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