Why and how have drug discovery strategies in pharma changed? what are the new mindsets?

In the pharmaceutical business, the long-run challenge of drug innovation is that the key phrase throughout R&D that refers to increasing the output of original drug candidate molecules. To extend R&D productivity, implementation of recent and strategic R&D orientations to develop new approaches or systems to spot hits and leads expeditiously has taken place and enabled all scientists operating within the drug discovery domain to develop innovative medicines for the twenty-first century.